Endocrine Abstracts

Introduction: Recently, PCSK9 inhibitors have been approved in our country for familial hypercholesterolemia and for patients with cardiovascular diseases. They are still scarce data in real life patients effects.Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific unit of familial dyslipidemia and the effect on lipid profile and other clinical variables.Material and methods: Data from patie...

Objective: This study reviews the clinical characteristics of patients treated in a Multidisciplinary Diabetic Foot Unit (MDFU) and analyzes the rate of diabetic foot amputations and the risk factors associated.Design and methods: A retrospective cohort study including data from all patients who attended the MDFU during December 2017-October 2018 period. The patients were followed until January 2019. Clinical, anthropometric, and biochemical parameters (...

Introduction: Primary hyperaldosteronism (PH) is characterized by autonomous adrenal aldosterone (A) hypersecretion. Unilateral adrenalectomy is the treatment of choice, when adrenal vein sampling (AVS) indicates lateralization of A secretion. To assure that each adrenal vein (AV) has been correctly sampled, cortisol levels in each adrenal vein must be higher than in the inferior vena cava. The adrenal gland cortisol/vena cava cortisol ratio is referred to as the selectivity i...

Objectives: To analyse the levels of anxiety, depression, impulsiveness, bulimic behaviour, concern about body image and the quality of life of patients included in the care process following bariatric surgery, in our field.Methods: Observational study of the patients included in the care process for bariatric surgery at University Hospital Puerta del Mar. Two cohorts were identified according to their situation before or after surgery. Studies were made...

Objectives: To determine the habits and lifestyle of the morbidly obese before and after bariatric surgery.Material and methods: Transversal study of two groups of morbidly obese patients attending the Endocrinology Unit of Puerta del Mar, Cádiz: one group before and the other after bariatric surgery. Clinical and analytical data of the patients was collected: socio-demographic and lifestyle characteristics, Bulit-R Questionnaire (Bulimia), BIS (imp...

The improvement of glycemic control and body weight reduction by GLP-1 receptor agonist (GLP1RA) has been demostred in randomized clinical trials, but comparative studies of the efficacy of different GLP1RA in real world and clinical practice setting are limited.Objectives: To compare the efficacy of liraglutide (LIRA), exenatide once weekly (EQW), and lisixenatide (LIXI) treatment in a real-world and clinical practice setting.Meth...

Objectives: To study blood pressure circadian pattern in patients with impaired fasting glucose (IFG) evaluated with ambulatory blood pressure monitoring (ABPM).Methods: Cross-sectional study evaluating patients taken from the Spanish ABPM Registry. Normoglycemia was defined as glucose <100 mg/dl and IFG as glucose 100–125 mg/dl. All patients underwent 24-h ABPM with a Spacelabs ambulatory blood pressure system. ABPM was performed according to s...

Precedents: Thirty-nine year old Woman. Classic phenylketonuria diagnosed for neonatal screening in Germany. Good adherence to the diet from the infancy, with good metabolic control. Not response to test with BH4.Pregnancy in 2007 with good controls of phenylalanine (Phe). Son with congenital cardiopathy.Evolution: In 2013 she planed new pregnancy, departing from very good controls (<4 mg/dl) and ingestion of 22–24 Phe&#14...

Introduction and objectives: Hyperglycemia is present in about 25% of hospitalized patients. His control is common deficient. Consequently it increases the average stay, infection rates and mortality. In order to improve we present a comprehensive protocol.Methods: We developed algorithms of subcutaneous insulin therapy for non-critical patients, insulin therapy i.v. for critical patients, management of hypoglycemia, fasting situations, diabetic ketoacid...

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...